Bolsa de Investigação - Pancreas Regulome (Mestre)
Experiência: interest in the field of transcriptional cis-regulation and ambition to eventually develop a PhD thesis in this field.
Several human pancreatic diseases have been characterized, being the diabetes the most common. Like others, this genetic disease is related to disrupted non-coding cis-regulatory elements (CREs) that culminate in altered gene expression. Although Genome Wide Association Studies support this hypothesis, it’s still unclear how mutations on CREs contribute to disease. The translation from the “non-coding code” to phenotype is an exciting and unexplored field that we will approach in this project with the help of the zebrafish as a suitable animal model. We aim to uncover the implications of the disruption of pancreas CREs and how they contribute to diabetes in vivo. A combination of the following approaches will be used in the context of transcriptional cis-regulation: - Access the chromatin state genome wide, using Chromatin Immunoprecipitation and ATAC-seq. - Crispr-Cas9 technology.
Área Científica: Biologia ou relacionada
Local: Porto - See map
Habilitações: Mestrado
Experiência: interest in the field of transcriptional cis-regulation and ambition to eventually develop a PhD thesis in this field.
Início: 15 de Março de 2017
Duração: 3 meses (renováveis até um máximo de 3 anos)
Montante: 980€
Abertura Concurso: 8 de Março de 2017
Deadline: CLOSED
Sem comentários:
Enviar um comentário